I always thought that it was just supposed to be Lord English's souls in there somehow, and that's why Bec killed it. Maybe that's what the Juju did to him? But then the Genesis Frog would presumably be cursed, and it seems fine.
Maybe the point of the curse will be that because LE's soul(s) was/were used in the creation of the Universe C, it'll be fated to be his origin? A nice ouroboros kinda thing, you know.
Oh, that would make sense. But because it would make sense, it probably won't happen LOL.