May be the most ambitious Homestuck FA.

Well, good luck with giving each of them a name and a personality.
The obvious risk is, you may not give them enough screentime/development/touch with the reader. But then, it depends on whether you want all of them to be main stars, or if you plan a small number to have the spotlight and the rest to be minor/background characters.
Homestuck has hundreds of characters, but the Felt members don't have the same status as the Trolls, let's say. That's a way to put it.
Another point is interaction between characters. If again, you want all of them to be in the spotlight, keeping track of relations and links will be a hell: only counting two-way relationships, you'll end up with 1047552 bonds to consider (1048576 if characters can be friends with themselves).
Of course, if you plan to have a major-minor-background dynamic, then 1024 charas would be less scary. You can give background charas very quick descriptions: grandma next door, silly baker, grumpy fisherman, town's fool, etc. All of them don't have to interact with each other, of course.
Still. That's a lot. especially if you plan to give them unique personalities. I don't know how anyone can come up with a thousand unique people. Even if I add my own OCs to Homestuck's charas, as well as cameos and scrapped ones, I don't think I'm anywhere near that bar.

But if you wanna do it, go ahead. That sounds crazy but someone has to do it.
That might be the weirdest Sburb session ever (if it is one).

Unless a majority of these characters are minor ones, then this idea could quickly fall on its face

Wait i realized something.
Can we move this to fan creations if its allowed?

Looked like a chumhandle, I apologize.

Should i go ahead and post in the cradle, or should i wait for more input? *Nudges Sharkalien*

I mean, if you have a good idea of where you're going with this, then sure. But there's no harm in waiting a little longer

Uh... my moderating powers only apply to Fan Adventures but not any of the other forums

I'll see if any other mods are on (goddamn, I'm so embarrassed)

I gotchoo.

... Ok, but let me put this into perspective: For each session you have to introduce ther characters, get them into the game, have them complete the game, then have them called in to assist the next. That takes a long time, especially if you want to add in enough stuff to make each session unique rather than just repeating the same thing over and over again, not to mention creating every single unique character. But let's say you're a god at this and do each session in a week. For 1024 people that's 256 sessions. 256*7=1792, 1792/365 ≈ 4.9. That means it will take you 5 years to complete this adventure (that .1 extra can go to the final confrontation, though good luck getting all of that in about 35 days...). (For reference, at 5 years since starting, Homestuck was on the Gigapause.) And that's only if you can not only somehow manage to cram each session into a week, but also work without a single hiatus. Good luck.